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KMID : 1159320170190030313
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Korean Journal of Vision Science
2017 Volume.19 No. 3 p.313 ~ p.322
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Physical Characteristics and Protein Adsorption Properties of Hydrogel Lenses Functionalized with an Interpenetrating Succinyl-Chitosan Network
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Lee Cheol-Woo
Jeong Hyun-Woo
Kim Ho-Joong
Ryu Geun-Chang
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Abstract
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Purpose: This study is to synthesize succinyl-chitosan(SCS) and investigate the physical properties and the protein adsorption abilities of the contact lenses prepared by an construction of interpenetrating polymer network(IPN) structures consisting of p(HEMA)-hydrogels and SCSs.
Methods: SCS was synthesized by reactions of chitosans with succinic anhydride. P(HEMA) hydrogels were prepared by the copoolymerization of HEMA, EGDMA, and NVP monomers in the presence of initiator AIBN, and the subsequent construction of IPN structures with hydrogels and SCSs resulted in the contact lenses. The water content, contact angle, optical properties, and surface roughness of the manufactured lenses were investigated and the adsorption of protein on the lenses was determined by the method of Lowry.
Results: The amounts of proteins adsorbed on the SCS-modified lenses decreased relative to that of the unmodified control. As the molecular weight of SCS increases, the resulting lenses showed the reduction in the protein adsorption and the water contact angle, and the increment in the water content, indicative of the increase in the wettability.
Conclusion: The construction of IPN structures consisting of SCSs and p(HEMA) hydrogels, can provide a strategy for development of contact lenses which are excellent in wettability and can reduce adsorption of proteins without deteriorating the physical properties of conventional contact lenses.
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KEYWORD
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Contact lenses , Protein , Succinyl-Chitosan , interpenetrating polymer network , hydrogel
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